Chorea Huntington ke lefu le sa foleng la liphatsa tsa lefutso la tsamaiso ea methapo e ka hlahang bocheng ba bongoaneng, empa hangata e qala ho bonahala ho batho ba lilemo li 30 ho isa ho tse 50. Ena ke boloetse bo tebileng, bo ntseng bo tsoela pele butle-butle, bo khetholloang ka mekhoa e fapaneng ea ho senya mefuta ea 'mele, e amang boko bo eketsehileng.
Lisosa tsa chorea ea Huntington
Joalokaha ho se ho boletsoe, choring ea Huntington ke lefu la liphatsa tsa lefutso, kahoo le futsitsoe ho batsoali ba kulang. Mofuta oa lefa la Huntington's chorea ke oa autosomal. Pathology e atile haholo ho banna. Ho boetse ho tsejoa hore karolo e itseng ho nts'etsopele ea chorea ea Huntington e bapaloa ke mafu a tšoaetsanoang, khatello ea kelello, tahi ea lithethefatsi.
Lefapha la hantingtin, le fumanoang ho batho bohle ka chromosome ea bone, le ikarabella bakeng sa ho ngolisoa ha protheine ea eponymous, eo mesebetsi ea eona e sa tsejoeng hantle kajeno. Protheine ena e fumanoa li-neurons tsa likarolo tse sa tšoaneng tsa boko. Lefu lena le hlaha ha liphatsa tsa lefutso li fetoha ka lebaka la ho lelefatsa ketane ea amino acid. Ha ho fumanoa li-amino acid tse itseng, protheine e qala ho ba le phello e chefo lisele tsa 'mele.
Matšoao a chorea ea Huntington
Lefu lena le khetholloa ke matšoao a ho hōla butle-butle, a kenyeletsang:
- mathata a kelello - fokotsa mohopolo, tlhokomelo, bokhoni ba ho nahana, botho ba fetoha;
- maloetse a mangata, a khetholloang ke mekhoa e fapaneng ea mesifa (haholo-holo, ho senya ka tsela e se nang moelelo oa mesifa ea sefahleho, matsoho le mahetleng, mehato ea li-spasmodic ea mahlo, liphetoho ho gait);
- puo e thata, e senyehileng;
- mathata a ho robala ;
- bothata ba ho falla ha boithatelo;
- ho fokotsa ho nyatsa boitšoaro ba motho le boemo ba hae;
- litlhaselo tse sa utloahaleng tsa ho tšoha, ho hloka thahasello le ho tepella maikutlong ;
- mekhoa e mebe e eketsehileng;
- ho kopanela liphate;
- nts'etso-pele ea 'dementia' ('dementia');
- endocrine le li-neurotrophic disorders.
Pakeng tsa ponahalo ea matšoao a methapo ea maikutlo le ea kelello ho ka 'na ha e-ba le lekhalo la lilemo tse' maloa. Ha nako e ntse e feta, mathata a fapa-fapaneng a hlaha: ho hloleha ha pelo, pneumonia, cachexia. Tšepo ea bophelo ea bakuli ba chorea ea Huntington e fapane, empa ka karolelano ke lilemo tse ka bang 15. Lefu le tloaelehileng ka ho fetisisa le bakoa ke mathata.
Phekolo ea chorea ea Huntington
Ka nako eo lefu lena le nkoa le sa phekolehe. Meriana e ka fokotsa tsoelo-pele ea eona, hape e fokotsa ponahatso ea matšoao a fokotsang boleng ba bophelo. Ho finyella sena, bakuli ba abeloa meriana e 'maloa, ho akarelletsa le:
- Tetrabenazine - sesebelisoa se khethehileng sa ho fokotsa matla a matšoao a choring ea Huntington;
- mokhoa oa antiparkinsonian o bolela - ho thusa ho etsa hore hypokineia le ho tiea ha mesifa;
- oli ea valproic - ho fokotsa lefu la myoclonic hyperkinesia;
- khetha serotonin reuptake inhibitors le mirtazapine - ho felisa ho tepella maikutlong;
- li-antipsychotics tse nang le li-antipychotic - tse nang le mathata a kelello le boitšoaro;
- li-neuroleptics le benzodiazepines - ho fokotsa ponahalo ea chorea;
- bahanyetsi ba dopamine - ho thibela hyperkinesis;
- litokisetso tsa valproic acid - tse nang le maqeba a myoclonic.
Tse ling tsa lithethefatsi tse ka holimo li thibetsoe hore li sebelisoe naheng ea rona, ho sa tsotellehe tsoelo-pele ea bona e phahameng. Ka hona, bakuli ba bangata ba ea linaheng tse ling ho ea kalafo.