Pro-progesterone ea 17-OH kapa 17-hydroxyprogesterone ke hormone ea steroid e hlahisoang ka mokelikeli oa adrenal 'me ke pele ho li-hormone tse kang cortisol, estradiol le testosterone. E boetse e hlahisoa ka litšoelesa tsa thobalano, follicle e hōlileng ka ho feletseng, mosehla 'meleng le placenta' me tlas'a tšusumetso ea enzyme ea 17-20 lyase e fetoha li-hormone tsa thobalano. E latelang, re tla tšohla hore na progesterone e 17 e phetha karolo efe 'meleng oa mosali ea se nang moimana le nakong ea bokhachane le matšoao a keketseho ea eona le ho se sebetse.
Likokoana-hloko tsa hormone ea 17-oh progesterone
Palo ea motho e mong le e mong ea 17-OH progesterone e fetoha ka hare ho lihora tse 24. Ka lebaka leo, mahlakore a eona a holimo a tsejoa lihora tsa hoseng, 'me bonyane - bosiu. Progesterone ea 17-OH ho basali e fapana ho latela boemo ba ho ea khoeling. Ho eketseha ho hoholo ha tekanyo ea hormone ena ho tsejoa motšehare oa ho tlosoa ha ovulation (pele ho eketseha ho hoholo ha hormone ea luteinizing). Progesterone ea 17-OH e boemong ba follicular e fokotseha ka potlako, e fihla tekanyo e fokolang karolong ea ho phalla.
Joale nahana ka litekanyetso tse tloaelehileng tsa progesterone ea 17-OH, ho itšetlehile ka mohato oa nako ea ho ea khoeling:
- karolong ea luteal - 0.99-11.51 nmol / l;
- ka karolo ea follicular - 1,24-8,24 nmol / l;
- ka mohato oa ovulation - 0,91-4,24 nmol / l.
Pro-progesterone ea 17-OH nakong ea bokhachane e eketseha, e fihla ho litekanyetso tsa eona tse phahameng libeke tse sa tsoa feta. Nakong ea bokhachane, placenta e boetse e arabela ka ho qala ha hormone ena ea steroid. Ak'u inahanele bohlokoa ba tumello ea progesterone ea 17-OH nakong ea bokhachane:
- ka halofo ea pele - 3,55-17,03 nmol / l;
- ka halofo ea bobeli - 3,55-20 nmol / l;
- ka halofo ea boraro - 3.75-33.33 nmol / l.
Ha ho e-na le meriana ea pele le nakong ea ho ikhula, boemo ba hormone 17-OH progesterone bo fokotseha haholo 'me bo fihla ho 0,39-1.55 nmol / l.
Fetola ka tekanyo ea 17-OH progesterone - ho hlahlojoa le matšoao
Progesterone e sa lekaneng ea 17-OH maling hangata e baka sesosa sa adrenal hypoplasia 'me e ka kopanngoa le tlhahiso e lekaneng ea lihomone tse ling. Ha e le hantle, e ka iponahatsa e le mofuta oa lefu la Addison, 'me bashanyana ba se ba sa ntsane ba ntlafatsa liphatsa tsa lefutso tsa ka ntle.
Ho eketseha ha progesterone ea 17-OH e ka hlokomeloa feela nakong ea bokhachane, maemong a mang e bontša ho kula. Ka hona, progesterone e phahameng ea 17-OH e ka ba letšoao la lihlahala tse nyenyane, mae a bomme (mekhoa e mebe le polycystosis) le mathata a liphatsa tsa lefutso la adrenal cortex.
Ha e le hantle, keketseho ea progesterone ea 17-OH e ka bonahala:
- ho tlōla ha nako ea ho ea khoeling;
- ho hloka matla;
- ho ntša mpa ntle ho nako;
- ho tsoaloa kapa ho shoa ha masea;
- ho eketseha ha progesterone 17-OH e ka bonahatsoa ke li-acne (li-pimples);
- Haeba progesterone ea 17-OH e phahame, testosterone e ka boela ea phahama. Sena se ka bonahala ka mokhoa oa ho eketseha ha moriri sefahlehong le 'meleng (mofuta oa moriri oa banna).
Boemo ba progesterone ea 17-OH e ka khethoa ka ho hlahloba serum
Kahoo, re hlahlobile karolo ea likokoana-hloko 'meleng oa hormone 17-OH progesterone le litekanyetso tsa eona tse lumelloang ho basali. Ho fokotseha ha tekanyo ea hormone ena ho ka etsahala ha feela nakong ea ho ipolaea, 'me keketseho ea eona e nkoa e tloaelehile ho pholletsa le bokhachane. Phetoho ea boemo ba progesterone ea 17-OH maemong a mang e ka 'na ea e-ba e' ngoe ea matšoao a lefu la li-adrenal le la mae a bomme, le lebisang ho hyperandrogenism, ho se sebetse kapa ho ntša mpa ntle ho nako.