Beta-blockers - lenane la lithethefatsi

Li-beta-blockers li bitsoa lithethefatsi tse ka thibelang batho ba amohelang beta-adrenergic ka nakoana. Hangata chelete ena e abeloa ha:

• phekolo ea lefu la pelo;
• tlhokahalo ea ho thibela tšoaetso ea moricardial e tsoelang pele;
• phekolo ea khatello ea meriana.

Li-receptor tsa beta-adrenergic ke eng?

Li-receptor tsa Beta-adrenergic ke li-receptor tse amohelang li-hormone adrenaline le noradrenaline 'me li arotsoe ka lihlopha tse tharo:

1. β1 - haholo-holo sebakeng sa pelo, 'me ka ts'ebetso ea bona ho na le keketseho ea matla le makhetlo a ho thibela pelo, khatello ea mali e phahama; Hape li-receptor tsa β1-adrenergic li teng liphio 'me li sebetsa joaloka li-receptors tsa lisebelisoa tse haufi le lobe;
2. β2 - li-receptors, tse fumanoang ka bronchioles le ho etsa hore ho atolosoe le ho felisoa ha bronchospasme; Hape li-receptor tsena li le lisele tse hlakileng, 'me ho tsosolosa ha tsona ke li-hormone ho khothalletsa ho hlaphoheloa ha glycogen (polokelo ea polysaccharide) le ho lokolloa ha tsoekere maling;
3. β3 - e fumanehang ka mahlaseli a adipose, tlas'a tšusumetso ea li-hormone e etsa hore ho be le mefuta e mengata ea mafura, e bakang matla le ho eketseha ha mocheso.

Lenane le lenane la lithethefatsi tsa beta-blockers

Ho itšetlehile ka hore na li-receptor li ameha hakae ke beta-blockers, li etsa hore li thibe, lithethefatsi tsena li arotsoe ka lihlopha tse peli tse ka sehloohong.

Khetho (cardioselective) beta-blockers

Ketso ea lithethefatsi tsena e khetha le ho thibela li-β1-adrenergic receptors (ha li ame li-β2-receptors), haholo-holo liphello tsa pelo tse boletsoeng:

• fokotseha ka matla a liphapang tsa pelo;
• ho fokotseha ha lebelo la pelo;
• ho hatella ho khanna ka mokhoa oa atrio-ventricular;
• fokotseha ho khaotsa pelo.

Sehlopha sena se kenyelletsa lithethefatsi tse joalo

• Atenolol (Sethenoben, Prinorm, Hypoten, Tenolol, joalo-joalo);
• Bisoprolol (Concor, Bizomor, Coronale, Bisogamma, joalo-joalo);
• betaxolol (Glaoks, Kerlon, Lokren, Betoptik, joalo-joalo);
• metoprolol (Vazocardin, Betaloc, Corvitol, Logimax, joalo-joalo);
• Nebivolol (Binelol, Nebilet, Nebivator);
• talinolol (Cordanum);
• esmolol (Breviblock).

Li-beta-blockers tse sa khethollang

Lithethefatsi tsena li khona ho thibela li-adrenoreceptor tse peli tsa β1 le β2, li na le liketso tse matlafatsang, tse khahlanong le khalefo, li-antiarrhymmic le li-membrane-stabilizing action. Lithethefatsi tsena li boetse li etsa hore ho be le keketseho ea molumo oa bronchi, molumo oa arterioles, molumo oa popelo, le ho hōla ha methapo ea li-vascular resistance.

Sena se akarelletsa lithethefatsi tse latelang:

• propranolol (Anaprilin, Propamine, Noloten, Inderal, joalo-joalo);
• bopindolol (Sandinorm);
• Levobunolol (Wistagen);
• nadolol (Korgard);
• Oxprenolol (Trazicor, Coretal);
• ovonol (Vistagan);
• pindolol (Vickin, Viscaldix);
• sotalol (Sotagexal, Sotalex).
• timolol (Okumed, Arutimol, Fotil, Glukomol, joalo-joalo).

Beta-blockers ea moloko oa moraorao

Litokisetso tsa moloko o mocha, oa boraro, o khetholloa ka thepa e eketsehileng ea vasodilating ka lebaka la ho thibela li-receptor tsa alpha-adrenergic. Lethathamo la li-beta tsa kajeno li akarelletsa:

• carvedilol (Acridilol, Vedicardol, Carvedigamma, Rekardium, joalo-joalo);
• Celiprolol (Tselipres);
• bucindolol.

Ho hlakisa lenane la lithethefatsi tsa beta-blockers le tachycardia, ho bohlokoa ho hlokomela hore tabeng ena, lithethefatsi tse sebetsang ka ho fetisisa tse thusang ho fokotsa lebelo la pelo, ke chelete e thehiloeng ho bisoprolol le propranolol.

Litlhaloso tse amanang le tšebeliso ea beta-blockers

Litaba tse ka sehloohong tsa lithethefatsi tsena ke:

• lefu la ho fokola ha pelo;
• khatello e tlase ea mali;
• lefu la bofokoli ba pono ea sinus;
• pathology ea lisele tsa methapo;
• bradycardia;
• ho tšoha ha pelo ;
• atrioventricular block ea boemo ba bobeli kapa ba boraro.